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Viruses, Vol. 12, Pages 1434: Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity
Poranen Veijo Hukkanen Acyclovir is the drug of choice for the treatment of herpes simplex virus (HSV) infections. Acyclovir-resistant HSV strains may emerge, especially during long-term drug use, and subsequently cause difficult-to-treat exacerbations. Previously, we set up a novel treatment approach, based on enzymatically synthesized pools of siRNAs, or siRNA swarms. These swarms can cover kilobases-long target sequences, reducing the likelihood of resistance to treatment. Swarms targeting the UL29 essential gene of HSV-1 have demonstrated high efficacy against HSV-1 in vitro and in vivo. Here, we assessed the an...
Source: Viruses - December 13, 2020 Category: Virology Authors: Kiira Kalke Jenni Lehtinen Jelena Gnjatovic Liisa M. Lund Marie C. Nyman Henrik Paavilainen Julius Orpana Tuomas Lasanen Fanny Frejborg Alesia A. Levanova Tytti Vuorinen Minna M. Poranen Veijo Hukkanen Tags: Article Source Type: research