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Viruses, Vol. 9, Pages 201: Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes
Nazira El-Hage Under physiological conditions, the function of astrocytes in providing brain metabolic support is compromised under pathophysiological conditions caused by human immunodeficiency virus (HIV) and opioids. Herein, we examined the role of autophagy, a lysosomal degradation pathway important for cellular homeostasis and survival, as a potential regulatory mechanism during pathophysiological conditions in primary human astrocytes. Blocking autophagy with small interfering RNA (siRNA) targeting BECN1, but not the Autophagy-related 5 (ATG5) gene, caused a significant decrease in HIV and morphine-induced intra...
Source: Viruses - July 28, 2017 Category: Virology Authors: Myosotys Rodriguez Jessica Lapierre Chet Ojha Hary Estrada-Bueno Seth Dever David Gewirtz Fatah Kashanchi Nazira El-Hage Tags: Article Source Type: research