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Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for Huntingtin gene silencing across an in vitro BBB model
In conclusion, the CD platform is a promising option for delivery of siRNA-based therapeutics for HD with wider potential to treat other diseases with a genetically validated target in the central nervous system.PMID:34793942 | DOI:10.1016/j.ejpb.2021.11.003
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 18, 2021 Category: Drugs & Pharmacology Authors: Monique C P Mendon ça Michael F Cronin John F Cryan Caitriona M O'Driscoll Source Type: research

Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: in-vitro analysis.
Abstract In man brain cancer is an aggressive, malignant form of tumor, it is highly infiltrative in nature, is associated with cellular heterogeneity and affects cerebral hemispheres of the brain. Current drug therapies are inadequate and an unmet clinical need exists to develop new improved therapeutics. The ability to silence genes associated with disease progression by using short interfering RNA (siRNA) presents the potential to develop safe and effective therapies. In this work, in order to protect the siRNA from degradation, promote cell specific uptake and enhance gene silencing efficiency, a PEGylated cyc...
Source: European Journal of Pharmaceutical Sciences - February 19, 2015 Category: Drugs & Pharmacology Authors: Gooding M, Malhotra M, McCarthy DJ, Godinho BM, Cryan JF, Darcy R, O'Driscoll CM Tags: Eur J Pharm Sci Source Type: research