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Mirror siRNAs loading for dual delivery of doxorubicin and autophagy regulation siRNA for multidrug reversing chemotherapy
Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): Bo Yang, Anlin Hao, Lin Chen
Source: Biomedicine and Pharmacotherapy - July 23, 2020 Category: Drugs & Pharmacology Source Type: research

Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Yinxue Song, Bin Zhou, Xiangyang Du, Yong Wang, Jie Zhang, Yanqiu Ai, Zongjiang Xia, Gaofeng Zhao
Source: Biomedicine and Pharmacotherapy - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

Non‐coding RNA LOXL1-AS1 exhibits oncogenic activity in ovarian cancer via regulation of miR‐18b‐5p/VMA21 axis
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Fang Xue, Yan Hua Xu, Cheng Cheng Shen, Zhen Li Qin, Hai Bin ZhouAbstractLong non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene in multiple tumor types. In the current study, we illuminated the precise roles of LOXL1-AS1 in the development of ovarian cancer. LOXL1-AS1 is significantly overexpressed in ovarian carcinoma tissue compared with adjacent non‐cancerous sample. The luciferase reporter gene assay reveals the...
Source: Biomedicine and Pharmacotherapy - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2
ConclusionOverall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment.
Source: Biomedicine and Pharmacotherapy - February 9, 2020 Category: Drugs & Pharmacology Source Type: research

Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Katsuya Iuchi, Yuji Tasaki, Sayo Shirai, Hisashi HisatomiAbstractAn increasing number of metal-based compounds, including arsenic trioxide, auranofin, and cisplatin, have been reported to have antitumor activity. Their beneficial effects are controlled by a transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2). In response to oxidative stress, NRF2 induces the expression of cytoprotective genes. NRF2 protein levels are regulated by Kelch-like ECH-associated protein 1 (KEAP1) via ubiquitination. Bi-chlorodibenzo[c,f][1,5...
Source: Biomedicine and Pharmacotherapy - January 29, 2020 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA DLEU2 promotes the progression of esophageal cancer through miR-30e-5p/E2F7 axis
ConclusionsOur findings revealed the pro-oncogenic role of lncRNA DLEU2 and E2F7 in the progression of EC, suggesting that lncRNA DLEU2 exerts ceRNA functions in EC through regulating miR-30e-5p/E2F7 axis.
Source: Biomedicine and Pharmacotherapy - December 27, 2019 Category: Drugs & Pharmacology Source Type: research

Follistatin-like 3, an activin A binding protein, is involved in early pregnancy loss
ConclusionsFSTL3 plays a biological role in the establishment and maintenance of normal pregnancy. Moreover, FSTL3 may be involved in the early pregnancy loss via neutralizing the elevated activin A.
Source: Biomedicine and Pharmacotherapy - November 26, 2019 Category: Drugs & Pharmacology Source Type: research

Interaction between hyperphosphorylated tau and pyroptosis in forskolin and streptozotocin induced AD models
In this study, we used two hyperphosphorylated tau models, intracerebroventricular (ICV) forskolin (FSK, a PKA activator) rat model and ICV-streptozotocin (STZ) rat model; also, FSK and STZ treated PC12 cells as in vitro models to test the relationship between hyperphosphorylated tau proteins and pyroptosis. We found that FSK and STZ significantly increased the hyperphosphorylated tau level, pyroptosis-related protein in PC12 cell and rats’ brain, and inhibited the activity of caspase-1 by caspase-1 inhibitor, caspase-1 siRNA, or incubated with Interleukin(IL)-1β/IL-18 neutralizing antibody could notably alleviate the F...
Source: Biomedicine and Pharmacotherapy - November 26, 2019 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis
ConclusionCollectively, these results suggest that CASC21 functions as a ceRNA that plays an oncogenic role in the progression of colorectal cancer by regulating the miR-7-5p/YAP1 axis. LncRNA CASC21 might be a potential target for therapy of colorectal cancer.
Source: Biomedicine and Pharmacotherapy - November 26, 2019 Category: Drugs & Pharmacology Source Type: research

15-Lipoxygenase-1 in osteoblasts promotes TGF-β1 expression via inhibiting autophagy in human osteoarthritis
ConclusionIn the present study, our findings suggested that 15-Lipoxygenase-1 in Osteoblasts Promotes TGF-β1 expression via inhibiting autophagy in human Osteoarthritis. These novel results suggested that 15-Lipoxygenase-1 expressed by subchondral bone osteoblasts might be a promising therapeutic target in human OA.Graphical abstract
Source: Biomedicine and Pharmacotherapy - November 5, 2019 Category: Drugs & Pharmacology Source Type: research

Hic-5 in pancreatic stellate cells affects proliferation, apoptosis, migration, invasion of pancreatic cancer cells and postoperative survival time of pancreatic cancer
Publication date: January 2020Source: Biomedicine & Pharmacotherapy, Volume 121Author(s): Baolin Qian, Liping Wei, Zhongqiu Yang, Qinyuan He, Hao Chen, Ankang Wang, Dayin Yang, Qiu Li, Jing Li, Silin Zheng, Wenguang FuAbstractPancreatic cancer is one of the most severe types of tumors, with a 5-year survival rate of less than 7%. The prognosis and treatment of pancreatic cancer are largely limited by the extent of tumor invasion and the presence of lymph node and distant metastases. Therefore, exploring the biological behavior of pancreatic cancer cells (PCCs) is extremely important for the understanding, diagnosis, and tr...
Source: Biomedicine and Pharmacotherapy - November 2, 2019 Category: Drugs & Pharmacology Source Type: research

Glucagon-like peptide-1 receptor expression and its functions are regulated by androgen
In this study, Glp1r mRNA was found widely expressed in normal male mice and its levels were positively correlated with the serum testosterone (T) concentrations. Using mouse insulinoma 6 (MIN6) cells, which highly express GLP-1R, we observed GLP-1R was upregulated both at transcriptional and protein levels induced by dihydrotestosterone (DHT) and was downregulated by androgen receptor inhibitor ARN-509 or small interfering RNA (siRNA) targeting Glp1r mRNA. In normal C57BL/6 mice and db/db mice, Glp1r mRNA levels in the pancreases increased in the DHT treatment group and decreased in the ARN-509 treatment group. And the in...
Source: Biomedicine and Pharmacotherapy - October 24, 2019 Category: Drugs & Pharmacology Source Type: research

AGEs impair Kv channel-mediated vasodilation of coronary arteries by activating the NF-κB signaling pathway in ZDF rats
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Qingbo Liu, Bing Hua, Wen Su, Beibing Di, Shandong Yu, Side Gao, Huirong Liu, Xueqiao Zhao, Weiping Li, Hongwei LiAbstractExcessive formation of advanced glycation end products (AGEs) impairs voltage-gated potassium (Kv) channels in rat coronary artery smooth muscle cells (CSMCs), resulting in weakened Kv-mediated coronary vasodilation. We hypothesized that induction of the nuclear factor-κB (NF-κB) signaling pathway by AGEs plays a significant role in the regulation of Kv channel-mediated vasodilation in Zucker diabetic fatty (ZDF...
Source: Biomedicine and Pharmacotherapy - October 18, 2019 Category: Drugs & Pharmacology Source Type: research

Antitumor effects of disulfiram/copper complex in the poorly-differentiated nasopharyngeal carcinoma cells via activating ClC-3 chloride channel
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Xiao Xu, Jingkui Xu, Chongyu Zhao, Xiuying Hou, Mengjia Li, Liwei Wang, Lixin Chen, Yehui Chen, Linyan Zhu, Haifeng YangAbstractThe enhancement of the anticancer activity by disulfiram (DSF) chelated with copper (DSF/Cu2+) has been investigated recently, while the underlying molecular mechanisms still need to be fully elucidated. Chloride channel-3 (ClC-3) is over-expressed in a variety of cancers and involves multiple tumor biological events. However, whether the over-expression of ClC-3 in tumor cells affects the sensitivity of ant...
Source: Biomedicine and Pharmacotherapy - October 12, 2019 Category: Drugs & Pharmacology Source Type: research

HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury
ConclusionsTogether, our studies indicated that HIF-1α synchronization regulate BNIP3 during OGD/R injury-induced autophagy in H9C2 cells, though BNIP3-induced autophagy acting as a survival mechanism.
Source: Biomedicine and Pharmacotherapy - October 5, 2019 Category: Drugs & Pharmacology Source Type: research

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