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TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I
In this study we explored the downstream signal of activated PARP1 to induce nuclear translocation of AIF in DPT-triggered glioma cell parthanatos. We showed that treatment with DPT (450 nM) induced PARP1 over-activation and Tax1 binding protein 1 (TAX1BP1) distribution to mitochondria in human U87, U251 and U118 glioma cells. PARP1 activation promoted TAX1BP1 distribution to mitochondria by depleting nicotinamide adenine dinucleotide (NAD+). Knockdown of TAX1BP1 with siRNA not only inhibited TAX1BP1 accumulation in mitochondria, but also alleviated nuclear translocation of AIF and glioma cell death. We demonstrated that T...
Source: Acta Pharmacologica Sinica - May 15, 2023 Category: Drugs & Pharmacology Authors: Xuan-Zhong Wang Shi-Peng Liang Xi Chen Zhen-Chuan Wang Chen Li Chun-Sheng Feng Shan Lu Chuan He Yu-Bo Wang Guang-Fan Chi Peng-Fei Ge Source Type: research

Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1 α pathway
In this study, we investigated the therapeutic effects of AG against renal injury in streptozocin (STZ)-induced diabetic mouse model. Diabetic mice were orally administered AG (5, 10 mg·kg-1·d-1) for 4 weeks. We showed that AG treatment greatly improved the proteinuria and ameliorated renal pathological damage without affecting the elevated blood glucose in diabetic mice. Furthermore, AG treatment significantly suppressed highly activated ALR2, and reduced oxidative stress in the kidney of diabetic mice and in high glucose and lipids-stimulated HK2 cells in vitro. We demonstrated that AG treatment modulated mitochondrial...
Source: Acta Pharmacologica Sinica - March 1, 2023 Category: Drugs & Pharmacology Authors: Meng-Yao Sun Hui-Jing Ye Chen Zheng Zi-Jie Jin Yan Yuan Hong-Bo Weng Source Type: research

GDF11 promotes wound healing in diabetic mice via stimulating HIF-1 ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization
Acta Pharmacol Sin. 2022 Nov 8. doi: 10.1038/s41401-022-01013-2. Online ahead of print.ABSTRACTNon-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound healing in both Type 1 DM (T1DM) and genetically engineered Type 2 diabetic db/db (T2DM) mice. In the present study, we elucidated the cellular and molecular mechanisms underlying the action of GDF11 on healing of small skin wound. Single round-shape full-thickness wound of 5-mm diameter with muscle and bone exposed was made o...
Source: Acta Pharmacologica Sinica - November 8, 2022 Category: Drugs & Pharmacology Authors: Ying Zhang Yi-Yuan Zhang Zhen-Wei Pan Qing-Qi Li Li-Hua Sun Xin Li Man-Yu Gong Xue-Wen Yang Yan-Ying Wang Hao-Dong Li Li-Na Xuan Ying-Chun Shao Meng-Meng Li Ming-Yu Zhang Qi Yu Zhange Li Xiao-Fang Zhang Dong-Hua Liu Yan-Meng Zhu Zhong-Yue Tan Yuan-Yuan Zh Source Type: research

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury
In conclusion, 11R-VIVIT administration inhibits IRI-induced NFAT2 activation and prevents AKI-to-CKD progression. Inhibiting NFAT2 may be a promising new therapeutic strategy for preventing renal fibrosis after IR-AKI.PMID:34937917 | DOI:10.1038/s41401-021-00833-y
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Zhi-Yong Xie Wei Dong Li Zhang Meng-Jie Wang Zhen-Meng Xiao Yu-Hua Zhang Wan-Xin Shi Ying Huang Yan Yang Cui-Li Li Lei Fu Xing-Chen Zhao Rui-Zhao Li Zhi-Lian Li Yuan-Han Chen Zhi-Ming Ye Shuang-Xin Liu Zheng Dong Xin-Ling Liang Source Type: research

Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF- κB p65 pathway
In this study, we evaluated the efficacy of zld1039 in the treatment of cisplatin-induced AKI in mice. Before injection of cisplatin (20 mg/kg, i.p.), mice were administered zld1039 (100, 200 mg/kg, i.g.) once, then in the following 3 days. We found that cisplatin-treated mice displayed serious AKI symptoms, evidenced by kidney dysfunction and kidney histological injury, accompanied by EZH2 upregulation in the nucleus of renal tubular epithelial cells. Administration of zld1039 dose-dependently alleviated renal dysfunction as well as the histological injury, inflammation and cell apoptosis in cisplatin-treated mice. We rev...
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Li Wen Shao-Hua Tao Fan Guo Ling-Zhi Li Hong-Liu Yang Yan Liang Li-Dan Zhang Liang Ma Ping Fu Source Type: research

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury
In conclusion, 11R-VIVIT administration inhibits IRI-induced NFAT2 activation and prevents AKI-to-CKD progression. Inhibiting NFAT2 may be a promising new therapeutic strategy for preventing renal fibrosis after IR-AKI.PMID:34937917 | DOI:10.1038/s41401-021-00833-y
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Zhi-Yong Xie Wei Dong Li Zhang Meng-Jie Wang Zhen-Meng Xiao Yu-Hua Zhang Wan-Xin Shi Ying Huang Yan Yang Cui-Li Li Lei Fu Xing-Chen Zhao Rui-Zhao Li Zhi-Lian Li Yuan-Han Chen Zhi-Ming Ye Shuang-Xin Liu Zheng Dong Xin-Ling Liang Source Type: research

Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF- κB p65 pathway
In this study, we evaluated the efficacy of zld1039 in the treatment of cisplatin-induced AKI in mice. Before injection of cisplatin (20 mg/kg, i.p.), mice were administered zld1039 (100, 200 mg/kg, i.g.) once, then in the following 3 days. We found that cisplatin-treated mice displayed serious AKI symptoms, evidenced by kidney dysfunction and kidney histological injury, accompanied by EZH2 upregulation in the nucleus of renal tubular epithelial cells. Administration of zld1039 dose-dependently alleviated renal dysfunction as well as the histological injury, inflammation and cell apoptosis in cisplatin-treated mice. We rev...
Source: Acta Pharmacologica Sinica - December 23, 2021 Category: Drugs & Pharmacology Authors: Li Wen Shao-Hua Tao Fan Guo Ling-Zhi Li Hong-Liu Yang Yan Liang Li-Dan Zhang Liang Ma Ping Fu Source Type: research

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