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VPS34-IN1 induces apoptosis of ER  + breast cancer cells via activating PERK/ATF4/CHOP pathway
Biochem Pharmacol. 2023 Jun 6:115634. doi: 10.1016/j.bcp.2023.115634. Online ahead of print.ABSTRACTVPS34-IN1 is a specific selective inhibitor of Class III Phosphatidylinositol 3-kinase (PI3K) and has been shown to exhibit a significant antitumor effect in leukemia and liver cancer. In current study, we focused on the anticancer effect and potential mechanism of VPS34-IN1 in estrogen receptor positive (ER + ) breast cancer. Our results revealed that VPS34-IN1 inhibited the viability of ER + breast cancer cells in vitro and in vivo. Flow cytometry and western blot analyses showed that VPS34-IN1 treatment induced breast can...
Source: Biochemical Pharmacology - June 8, 2023 Category: Drugs & Pharmacology Authors: Qiuya Wu Duanfang Zhou Zhengze Shen Bo Chen Gang Wang Lihong Wu Limei Zhang Xiaoli Li Lie Yuan Yuanli Wu Na Qu Weiying Zhou Source Type: research

Knockdown of Annexin A1 induces apoptosis, causing G2/M arrest and facilitating phagocytosis activity in human leukemia cell lines
Acta Pharm. 2021 Aug 30;72(1):109-122. doi: 10.2478/acph-2022-0005. Print 2022 Mar 1.ABSTRACTAnnexin A1 (ANXA1) is an endogenous protein involved in the control of proliferation, cell cycle, phagocytosis, and apoptosis in several types of cancer. To investigate the effects of ANXA1 knockdown in leukemia cells, transfection with specific ANXA1 siRNA was performed. Cell cycle and apoptosis were analyzed using flow cytometry and a mechanism involving caspases and Bcl-2 was quantified using Western blotting. Phagocytosis activity was evaluated using hematoxylin & eosin staining. The ANXA1 expression was significantly downr...
Source: Acta Pharmaceutica - January 18, 2023 Category: Drugs & Pharmacology Authors: Masyitah Hasan Endang Kumolosasi Ibrahim Jantan Malina Jasamai Norlaili Nazarudin Source Type: research

Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways
CONCLUSION: LNP formulations enable the delivery of RNA payloads into human airway epithelial cells, and in the murine respiratory system; they can be delivered to nasal mucosa and lower respiratory tract via intranasal delivery. The composition of helper lipids in LNPs crucially modulates transfection efficiencies in airway epithelia, highlighting their importance in effective delivery of therapeutic products for airways diseases.PMID:35688311 | DOI:10.1016/j.ejps.2022.106234
Source: European Journal of Pharmaceutical Sciences - June 10, 2022 Category: Drugs & Pharmacology Authors: A Tam J Kulkarni K An L Li D R Dorscheid G K Singhera P Bernatchez Gsd Reid Kyt Chan D Witzigmann P R Cullis D D Sin C J Lim Source Type: research

Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway
This study explored the effects and related molecular mechanisms of SFN on the proliferation of leukemia stem-like cells in acute myeloid leukemia cells. We found that SFN inhibited the proliferation of leukemia stem-like cells in vitro and in vivo. Meanwhile, we observed that SFN could regulate the stem characteristic of leukemia cells. After SFN treatment, the expression of the key players in the Sonic Hedgehog (Shh) signaling pathway was significantly decreased at the transcriptional and protein levels. To further determine the contribution of the Shh signaling molecular mechanism to SFN-mediated self-renewal capability...
Source: European Journal of Pharmacology - February 14, 2022 Category: Drugs & Pharmacology Authors: Fanping Wang Xiaoyu Huang Yanwei Sun Zhixin Li Ruili Sun Tiesuo Zhao Mingyong Wang Chunxia Yan Peijun Liu Source Type: research

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