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Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway
ConclusionsHSP90 could be a novel therapeutic target for angiosarcoma.
Source: British Journal of Dermatology - May 17, 2017 Category: Dermatology Authors: S. Yamada ‐Kanazawa, I. Kajihara, S. Fukushima, M. Jinnin, M. Masuzawa, M. Masuzawa, Y. Amoh, D. Hoshina, R. Abe, H. Ihn Tags: Translational Research Source Type: research

Inhibition of HSP90 exerts anti ‐tumor effect on angiosarcoma: Involvement of VEGF signaling pathway
ConclusionsHSP90 could be a novel therapeutic target for angiosarcoma.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - January 11, 2017 Category: Dermatology Authors: S. Yamada ‐Kanazawa, I. Kajihara, S. Fukushima, M. Jinnin, M. Masuzawa, M. Masuzawa, Y. Amoh, D. Hoshina, R. Abe, H. Ihn Tags: Original Article Source Type: research

Psoriasin (S100A7) promotes stress ‐induced angiogenesis
ConclusionsThese findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS‐induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features angiogenesis.
Source: British Journal of Dermatology - October 4, 2016 Category: Dermatology Authors: J. Vegfors, A. ‐K. Ekman, S.W. Stoll, C. Bivik Eding, C. Enerbäck Tags: Translational Research Source Type: research

USP2 as a potential link between miR ‐125b and psoriasis
ConclusionsShedding further light on the multi‐factorial causes of psoriasis is essential, if the goal is to progress towards finer control of therapeutic tools in disease management. Findings, such as the ones presented herein, are therefore necessary in order to achieve the future of personalized medicine.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - July 31, 2016 Category: Dermatology Authors: T. Wei, L. Folkersen, E. Biskup, N. Xu, V. Manfe, O. Niazi, R. Gniadecki Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits its antipsoriatic function through suppressing A20 expression and stabilizing negative regulators of the NF‐κB pathway.
Source: British Journal of Dermatology - May 13, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Translational Research Source Type: research

Psoriasin (S100A7) promotes stress‐induced angiogenesis
ConclusionThese findings suggest that psoriasin expression is promoted by oxidative stress in keratinocytes and amplifies the ROS‐induced expression of angiogenic factors relevant to psoriasis. Moreover, extracellularly secreted psoriasin may act on dermal endothelial cells to contribute to key features of the angiogenic process.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - May 6, 2016 Category: Dermatology Authors: J. Vegfors, A.‐K. Ekman, S.W. Stoll, C. Bivik Eding, C. Enerbäck Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the anti‐psoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits anti‐psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF‐κB pathway.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Original Article Source Type: research

Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through Notch and PI3K‐AKT signaling pathways
ConclusionsDeficiency of nicastrin gene in familial acne inversa may regulate proliferation and differentiation of keratinocytes mainly through Notch and PI3K‐AKT signaling pathways.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - October 16, 2015 Category: Dermatology Authors: X. Xiao, Y. He, C. Li, X. Zhang, H. Xu, B. Wang Tags: Original Article Source Type: research

Propranolol Targets Contractility of Infantile Hemangioma‐derived Pericytes
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - April 10, 2014 Category: Dermatology Authors: D. Lee, E. Boscolo, J.T. Durham, J.B. Mulliken, I.M. Herman, J. Bischoff Tags: Paediatric dermatology Source Type: research

Quercetagetin inhibits macrophage derived chemokine (MDC), a skin inflammatory chemokine, via the regulation of STAT1, SOCS1, and TGF‐β1 in HaCaT human keratinocytes
ConclusionsThese results suggest that quercetagetin may be the potent inhibitor on STAT1 signal, potentially be claimed as a new molecular target for anti‐inflammation treatment, and may thus have therapeutic applications as an immune modulator in inflammatory diseases such as AD.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - March 6, 2014 Category: Dermatology Authors: G.‐J. Kang, S.‐C. Han, N.‐J. Kang, D.‐H Koo, D.‐B. Park, S.‐Y. Eun, H.‐K. Kang, E.‐S. Yoo Tags: Clinical and laboratory investigations Source Type: research