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482 Inhibition of cyclooxygenase-2 and prostaglandin E-PGE receptor 4 pathway restores ultraviolet B-induced ATP2A2/SERCA2 downregulation in keratinocytes
Background: ATP2A2 encoding the sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase2 (SERCA2) is a responsible gene for Darier disease (DD). Ultraviolet (UV) B irradiation downregulates ATP2A2/SERCA2 expression in keratinocytes, whereas cyclooxygenase-2 (COX-2) expression is dramatically upregulated by UVB. Objectives: To analyze the involvement of COX-2 and subsequent Prostaglandin E (PGE) -PGE receptor signaling in ATP2A2/SERCA2 expression. Methods: Normal human keratinocytes (NHKs) were transfected with COX-2 siRNA, PGE receptor (EP1-4) siRNA and treated with COX-2 inhibitor, celecoxib, to evaluate the effect of COX-2 and P...
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: M. Kaga-Kamijo, A. Wada, R. Mineki, T. Sakanishi, C. Nishiyama, S. Ikeda Tags: Genetic Disease, Gene Regulation and Gene Therapy Source Type: research