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043 Mechanism of action of propranolol in Infantile Hemangioma: New insights from a xenograft model
8 years after propranolol was found efficacious in infantile hemangioma (IH), therapeutic mechanisms remain elusive. It has been shown, in an ovarian cancer model, that ADRB2 signaling is key for chronic stress induced tumor growth. In this model, tumor promotion is abolished by propranolol or ADRB2 siRNA but not by ADRB1 siRNA. In IH patients, after oral administration of 3 mg/kg/day of propranolol, plasma Cmax is below 1 μM, whereas propranolol has been used in vitro at 100 μM and up to 50 mg/kg in mouse models.
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: F. Moisan, J. Nissen, P. Kaulanjan-Checkmodine, S. Prey, P. Dufourcq, T. Couffinhal, H. Rezvani, A. Taieb Tags: Clinical Outcomes Source Type: research