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Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro
AbstractSTUDY QUESTIONDoes proviral integration site for Moloney murine leukaemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery?SUMMARY ANSWERPIM1 kinase plays a critical role in foetal membranes in regulating pro-inflammatory and pro-labour mediators.WHAT IS KNOWN ALREADYInfection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes. PIM1 has been shown to have a role in immune regulation and inflammation in non-gestational tissues; however, its r...
Source: Molecular Human Reproduction - March 28, 2017 Category: Molecular Biology Source Type: research