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Resveratrol enhances transintestinal cholesterol excretion through selective activation of intestinal liver X receptor alpha
In conclusion, RSV could decrease circulating cholesterol levels through enhancing TICE and limiting cholesterol absorption via selective activation of intestinal LXRα.PMID:33631191 | DOI:10.1016/j.bcp.2021.114481
Source: Biochemical Pharmacology - February 25, 2021 Category: Drugs & Pharmacology Authors: Juan Pang Huihui Xu Xu Wang Xu Chen Qing Li Qiannan Liu Yiran You Hanyue Zhang Zhongliang Xu Yimin Zhao Yinghui Zhang Yan Yang Wenhua Ling Source Type: research

Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway
In this study, we investigated the mechanism of shear stress in microvascular I/R injury, and try to elucidate the downstream signaling pathways that inhibit CMECs apoptosis to reduce I/R injury. Our results demonstrated that shear stress inhibited the apoptosis protein, increased PECAM-1 expression and eNOS phosphorylation in hypoxia reoxygenated (H/R) CMECs. The mechanism of shear stress was related to up-regulated expression of YAP, the increased number of YAP entering the nucleus by dephosphorylation, the reduced number of TUNEL positive cells, increased miR-206 and inhibited protein level of PDCD4 in CMECs. However, s...
Source: Biochemical Pharmacology - February 21, 2021 Category: Drugs & Pharmacology Authors: Qianlong Zhang Yonggang Cao Yongsheng Liu Wei Huang Jing Ren Peng Wang Chao Song Kai Fan Lina Ba Lixin Wang Hongli Sun Source Type: research