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Comparative Study of the Effects of Ferrochelatase ‐siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low‐dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models
Red fluorescence caused by the accumulation of PpIX in endometrial cancer xenografts in nude mice after high ‐dose ALA injection could be detected easily byin  vivo animal imaging system, but low ‐dose ALA (1.0 mg kg−1) was injected into xenografts, there was no red fluorescence of tumor. However, knockdown of FECH in nude mice was performed by transfection with FECH ‐siRNA mediated by PEI and ultrasound microbubbles alone or in combination, then 1.0 mg kg−1 ALA was injected, apparent red fluorescence of the xenografts was observed, and the fluorescence intensity was PEI+ ultrasound microbubbles  >  PEI...
Source: Photochemistry and Photobiology - July 18, 2019 Category: Science Authors: Xian Zhang, Longfei Chen, Lvfen Gao, Xuesong Gao, Nan Li, Yuwei Song, Xinke Huang, Shaoqiang Lin, Xiaoyu Wang Tags: Research Article Source Type: research

Comparative Study of the Effects of FECH ‐siRNA Transfection Mediated by Ultrasound Microbubbles and PEI in Combination with Low‐dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models
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Source: Photochemistry and Photobiology - December 24, 2018 Category: Science Authors: Xian Zhang, Longfei Chen, Lvfen Gao, Xuesong Gao, Nan Li, Yuwei Song, Xinke Huang, Shaoqiang Lin, Xiaoyu Wang Tags: Research Article Source Type: research