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Source: Clinical and Experimental Pharmacology and Physiology
Procedure: Ultrasound
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Total 2 results found since Jan 2013.
Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1 α/DNMT3a pathway via a TRAAK-dependent manner
This study aimed to determine whether low-intensity pulsed ultrasound (LIPUS), a novel and safe apparatus, could alleviate hypoxia-induced cardiac fibrosis, and to elucidate the underlying mechanisms. Hypoxia (1% O2 ) and transverse aortic constriction (TAC) were performed on neonatal rat cardiac fibroblasts and mice to induce cardiac fibrosis, respectively. LIPUS irradiation was applied for 20 minutes every 6 hours for a total of 2 times in vitro, and every 2 days from 1 week before surgery to 4 weeks after surgery in vivo. We found that LIPUS dose-dependently attenuated hypoxia-induced cardiac fibroblast phenotypic conve...
Source: Clinical and Experimental Pharmacology and Physiology - August 3, 2021 Category: Drugs & Pharmacology Authors: Kun Zhao Liqing Weng Tianhua Xu Chuanxi Yang Jing Zhang Gehui Ni Xiasheng Guo Juan Tu Dong Zhang Wei Sun Xiangqing Kong Source Type: research
