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Total 2 results found since Jan 2013.
Targeted Nanoparticle for Co ‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis
This research paper describes a new therapeutic candidate based on a nanoparticle that co-delivers siRNA against human epidermal growth factor receptor type 2 (HER2), trastuzumab, and docetaxel to treat advanced HER2+ breast cancer. The nanotherapeutic is more effective and safer than the free drug counterparts. It inhibits drug-resistant orthotopic and brain-metastatic HER2+ breast tumors in mice. AbstractThe first-line treatment of advanced and metastatic human epidermal growth factor receptor type 2 (HER2+) breast cancer requires two HER2-targeting antibodies (trastuzumab and pertuzumab) and a taxane (docetaxel or pacli...
Source: Small - January 27, 2022 Category: Nanotechnology Authors: Worapol Ngamcherdtrakul,
Daniel S. Bejan,
William Cruz ‐Muñoz,
Moataz Reda,
Husam Y. Zaidan,
Natnaree Siriwon,
Suphalak Marshall,
Ruijie Wang,
Molly A. Nelson,
Justin P. C. Rehwaldt,
Joe W. Gray,
Kullervo Hynynen,
Wassana Yantasee Tags: Research Article Source Type: research
