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GSE145697 The role of lncRNA Sarrah in human cardiomyocytes
Contributors : Reinier A Boon ; D J TrembinskiSeries Type : Expression profiling by arrayOrganism : Homo sapiensLong non-coding RNAs (lncRNAs) contribute to (patho)physiological processes in the heart. Aging is the major risk factor for cardiovascular disease and cardiomyocyte apoptosis is an underlying cause for age-related cardiac dysfunction. RNA sequencing of cardiomyocytes from young and aged mouse hearts revealed several aging-regulated lncRNAs. An siRNA screen for caspase activity identified the aging-regulated lncRNA Sarrah (ENSMUST00000140003) as anti-apoptotic, which we confirmed in human cells (human SARRAH is a...
Source: GEO: Gene Expression Omnibus - February 22, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research