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Nitrilase 1 modulates lung tumor progression in vitro and in vivo.
In this study we aimed to determine the role of Nit1 in a transgenic mouse lung cancer model driven by a G12D Kras mutation. Nit1 knockout mice (Nit1-/-) were crossed with KrasG12D/+ mice to investigate whether a G12D Kras mutation and Nit1 inactivation interact to promote or inhibit the development of NSCLC. We found that lung tumorigenesis was suppressed in the Nit1-null background (Nit1-/-:KrasG12D/+). Micro-CT scans and gross tumor measurements demonstrated a 5-fold reduction in total tumor volumes compared to Nit1+/+KrasG12D/+ (p<0.01). Furthermore, we found that Nit1 is highly expressed in human lung cancer tissue...
Source: Oncotarget - March 13, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients.
CONCLUSIONS: The combination of siG12D-LODER™ and chemotherapy is well tolerated, safe and demonstrated a potential efficacy in patients with LAPC. NCT01188785. PMID: 26009994 [PubMed - as supplied by publisher]
Source: Oncotarget - May 28, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research