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The Role of Thrombin Deficiency on Skeletal Health
ConclusionThis study seeks to understand the underlying mechanism for bone disease in hemophilia. The results indicate that >85% prothrombin knockdown in wild-type mice starting at 3 weeks of age does not significantly alter skeletal health. This suggests that either 1) thrombin deficiency is not involved in the mechanism of decreased skeletal health in hemophilia or; 2) the role of thrombin deficiency occurs early in bone development (prior to 3 weeks of age). To evaluate these two potential explanations, thrombin deficiency needs to be evaluated earlier in development. Thrombin deficient mice are embryonically lethal....
Source: Blood - November 21, 2018 Category: Hematology Authors: Taylor, H. J., Goldscheitter, G., Taylor, J. A. Tags: 321. Blood Coagulation and Fibrinolytic Factors Source Type: research