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Role of Small Interfering RNA Silencing Protein Kinase C ‐α Gene on the Occurrence of Ultrafiltration Failure in Peritoneal Dialysis Rats
This study aims to explore the effect of PKC‐α gene silencing on the occurrence of ultrafiltration failure (UFF) in peritoneal dialysis (PD) rats. Forty‐eight male SD rats were collected to establish 5/6 renal resection uremic and uremic PD rats models. Rats were assigned into control, sham operation, uremia, PD‐2 W (peritoneal dialysis for 2 weeks), PD‐4 W (peritoneal dialysis for 4 weeks), negative control (NC) (peritoneal dialysis for 4 weeks, and injected 0.1 mg/kg blank plasmid into abdominal cavity) and PKC‐α siRNA (peritoneal dialysis for 4 weeks, and injected 0.1 mg/kg PKC‐α siRNA into abdomi...
Source: Journal of Cellular Biochemistry - May 9, 2017 Category: Biochemistry Authors: Zhi ‐Wei Sun, Jian Wang, Min Weng, Jian‐Zhong Tang, Jun‐Feng Wang, Jian Xu, Ling Lin, Hong‐Ling Yuan Tags: Article Source Type: research