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Source: Oncotarget
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Total 624 results found since Jan 2013.
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388.ABSTRACTGlypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression...
Source: Oncotarget - March 21, 2023 Category: Cancer & Oncology Authors: Fang Cheng Victor Ch érouvrier Hansson Grigorios Georgolopoulos Katrin Mani Source Type: research
Role of the prorenin receptor in endometrial cancer cell growth
Oncotarget. 2022 Apr 1;13:587-599. doi: 10.18632/oncotarget.28224. eCollection 2022.ABSTRACTEndometrial cancer is the most diagnosed gynecological malignancy. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer continues to rise. Emerging evidence suggests a putative role of the (pro)renin receptor ((P)RR), in the ontogenesis of endometrial cancer. The (P)RR is implicated in breast cancer and pancreatic carcinoma pathophysiology by virtue of its role in proliferation, angiogenesis, fibrosis, migration and invasion. Thus, we aimed to investigate the functional role of the (P)RR in hu...
Source: Oncotarget - April 11, 2022 Category: Cancer & Oncology Authors: Jacinta H Martin Riazuddin Mohammed Sarah J Delforce David A Skerrett-Byrne Celine Corbisier de Meaultsart Juhura G Almazi Andrew N Stephens Nicole M Verrills Evdokia Dimitriadis Yu Wang Eugenie R Lumbers Kirsty G Pringle Source Type: research
MYH9 binds to dNTPs via deoxyribose moiety and plays an important role in DNA synthesis
Oncotarget. 2022 Mar 14;13:534-550. doi: 10.18632/oncotarget.28219. eCollection 2022.ABSTRACTThe accepted notion of dNTP transport following cytoplasmic biosynthesis is 'facilitated diffusion'; however, whether this alone is sufficient for moving dNTPs for DNA synthesis remains an open question. The data presented here show that the MYH9 gene encoded heavy chain of non-muscle myosin IIA binds dNTPs potentially serving as a 'reservoir'. Pull-down assays showed that MYH9 present in the cytoplasmic, mitochondrial and nuclear compartments bind to DNA and this interaction is inhibited by dNTPs and 2-deoxyribose-5-phosphate (dRP...
Source: Oncotarget - March 21, 2022 Category: Cancer & Oncology Authors: Pratima Nangia-Makker Malathy P V Shekhar Victor Hogan Vitaly Balan Avraham Raz Source Type: research
