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Oroxylin A has therapeutic potential in acute myelogenous leukemia by dual effects targeting PPARγ and RXRα
Abstract Oroxylin A (OA) is a flavonoid derived from a Chinese herb that has previously been reported to inhibit the proliferation of several cancer cell lines. It is found that OA significantly inhibited the growth of myeloid leukemia cell lines and as xenografts in immunodeficient mice and primary blasts from acute myelogenous leukemia (AML) patients. Furthermore, OA‐induced cell cycle arrest and differentiation were observed in OA‐treated AML cell lines. OA‐induced increase of CD11b/CD14 expression was reversed by GW9662, a specific PPARγ inhibitor, or transient transfection with PPARγ siRNA. Docking study showe...
Source: International Journal of Cancer - August 13, 2013 Category: Cancer & Oncology Authors: Hui Hui, Yan Chen, Hao Yang, Kai Zhao, Qian Wang, Li Zhao, Xiaotang Wang, Zhiyu Li, Na Lu, Qinglong Guo Tags: Cancer Therapy Source Type: research