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Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF- κB/HPSE1 Signaling Pathway During Inflammation
Front Pharmacol. 2022 Jan 3;12:791841. doi: 10.3389/fphar.2021.791841. eCollection 2021.ABSTRACTTetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive. Vascular glycocalyx coating on the endothelium would be damaged and caused endothelial dysfunction in the inflammatory microenvironment, which was the initial factor of morbidity of many vascular diseases, such as atherosclerosis (AS). Here, we thoroughly investigated the molecular mechanism of TMP on vascular endot...
Source: Atherosclerosis - February 21, 2022 Category: Cardiology Authors: Jin Lei Peng Xiang Shengmei Zeng Le Chen Lei Zhang Zhiyi Yuan Jun Zhang Tingting Wang Ruihong Yu Wanping Zhang Issa Issoufou Ibrahim Limei Ma Chao Yu Source Type: research