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Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research

Modified Panax ginseng Extract Inhibits uPAR-Mediated αFormula: see textβ1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells.
Abstract Urokinase receptor (uPAR) is enhanced in many human cancer cells and is frequently an indicator of poor prognosis. Activation of [Formula: see text]1-integrin requires caveolin-1 and is regulated by uPAR. However, the underlying molecular mechanism responsible for the interaction between uPAR and [Formula: see text]1-integrin remains obscure. We found that modified regular Panax ginseng extract (MRGX) had a negative modulating effect on the uPAR/[Formula: see text]1-integrin interaction, disrupted the uPAR/integrin interaction by modulating caveoline-1, and caused early apoptosis in cancer cells. Addition...
Source: The American Journal of Chinese Medicine - July 18, 2016 Category: Complementary Medicine Authors: Hwang IH, Kwon YK, Cho CK, Lee YW, Sung JS, Joo JC, Lee KB, Yoo HS, Jang IS Tags: Am J Chin Med Source Type: research

Tanshinone IIA Prevents Leu27IGF-II-induced Cardiomyocyte Hypertrophy Mediated by Estrogen Receptor and Subsequent Akt Activation.
This study investigates the role of ER signaling in mediating the protective effects of tanshinone IIA on IGF-IIR-induced myocardial hypertrophy. Leu27IGF-II (IGF-II analog) was shown in this study to specifically activate IGF-IIR expression and ICI 182,780 (ICI), an ER antagonist used to investigate tanshinone IIA estrogenic activity. We demonstrated that tanshinone IIA significantly enhanced Akt phosphorylation through ER activation to inhibit Leu27IGF-II-induced calcineurin expression and subsequent NFATc3 nuclear translocation to suppress myocardial hypertrophy. Tanshinone IIA reduced the cell size and suppressed ANP a...
Source: The American Journal of Chinese Medicine - November 30, 2015 Category: Complementary Medicine Authors: Weng YS, Wang HF, Pai PY, Jong GP, Lai CH, Chung LC, Hsieh DJ, HsuanDay C, Kuo WW, Huang CY Tags: Am J Chin Med Source Type: research

Protocatechuic Acid from Alpinia oxyphylla Induces Schwann Cell Migration via ERK1/2, JNK and p38 Activation.
This study investigated the role of PCA in promoting neural regeneration and the underlying molecular mechanisms. Nerve regeneration is a complex physiological response that takes place after injury. Schwann cells play a crucial role in the endogenous repair of peripheral nerves due to their ability to proliferate and migrate. The role of PCA in Schwann cell migration was determined by assessing the induced migration potential of RSC96 Schwann cells. PCA induced changes in the expression of proteins of three MAPK pathways, as determined using Western blot analysis. In order to determine the roles of MAPK (ERK1/2, JNK, and ...
Source: The American Journal of Chinese Medicine - June 28, 2015 Category: Complementary Medicine Authors: Ju DT, Kuo WW, Ho TJ, Paul CR, Kuo CH, Viswanadha VP, Lin CC, Chen YS, Chang YM, Huang CY Tags: Am J Chin Med Source Type: research