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Promotion of ABCG2 gene expression by neolignans from Piper longum L
Biosci Biotechnol Biochem. 2023 Sep 14:zbad132. doi: 10.1093/bbb/zbad132. Online ahead of print.ABSTRACTWe focused on Piper longum L., an herbal drug produced in Myanmar, which has a renoprotective effect. Thus, we attempted to isolate and identify compounds that enhance the expression of the ABCG2 gene from the aerial parts of the plant except for the fruit. Among the various P. longum extracts, we isolated and identified the components. Using Caco-2 cells, the hABCG2 mRNA expression-enhancing effects of the isolated compounds were compared with the positive reference compound (3-methylcholanthrene: 3MC) using real-time P...
Source: Bioscience, Biotechnology, and Biochemistry - September 14, 2023 Category: Biochemistry Authors: Atsuyoshi Nishina Motohiko Ukiya Kazuki Motegi Risa Kiryu Daisuke Sato Mitsuru Sada Yuki Hori Hideo Satsu Kazuhiro Uemura Mamoru Koketsu Masayuki Ninomiya Lwin Mon Mon Myint Hirokazu Kimura Source Type: research