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Soluble klotho regulates bone differentiation by upregulating expression of the transcription factor EGR ‐1
AbstractKlotho is a transmembrane protein known to regulate aging and lifespan. Soluble klotho (sKl), a truncated form of klotho, regulates various cell signaling pathways, including bone development. Here, we investigated the relationship between sKl and the zinc ‐finger transcription factor early growth response protein 1 (EGR‐1) on bone formation. We find that sKl induces the expression of EGR‐1 mRNA and protein. Through mutational analysis, we identify the 130 bp region on the EGR‐1 promoter that is responsive to sKl overexpression. Additionally, sKl induces the expression of markers of bone differentiation (BM...
Source: FEBS Letters - September 18, 2019 Category: Biochemistry Authors: Nguyen Khanh Toan, Nguyen Chi Tai, Soo ‐A Kim, Sang‐Gun Ahn Tags: RESEARCH ARTICLES Source Type: research