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Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
J Exp Clin Cancer Res. 2022 Jul 1;41(1):214. doi: 10.1186/s13046-022-02406-1.ABSTRACTBACKGROUND: One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The RNA molecules with more than 200 nucleotides in length are known as lncRNAs and these epigenetic factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional and epigenetic levels. LncRNAs play vital biological functions in cells and in pathological events, hence their expression u...
Source: Clinical Prostate Cancer - June 30, 2022 Category: Cancer & Oncology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Elena Okina Mohammad Hossein Gholami Kiavash Hushmandi Mehrdad Hashemi Azuma Kalu Ali Zarrabi Noushin Nabavi Navid Rabiee Esmaeel Sharifi Hassan Karimi-Maleh Milad Ashrafizadeh Alan Prem Kumar Yuzhuo Wang Source Type: research