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Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury
In this study, a hypoxia/reoxygenation (H/R)-induced renal tubular epithelial cell (TEC) injury model and an ischaemia/reperfusion (I/R)-induced mouse AKI model were treated with CUR with or without mitochondrial inhibitors (rotenone and FCCP) or siRNA targeting mitochondrial transcription factor A (TFAM). Changes in mitochondrial function, inflammation, the antioxidant system and related pathways were analysed. In vitro, CUR suppressed NFκB activation and cytokine production and induced NRF2/HO-1 signalling in TECs under H/R conditions. CUR treatment also reduced mitochondrial ROS (mtROS) and mitochondrial fragmentation ...
Source: Molecular Medicine - September 17, 2021 Category: Molecular Biology Authors: Ling Li Shuyun Liu Yijie Zhou Meng Zhao Yizhuo Wang Chengshi Wang Peng Lou Rongshuang Huang Liang Ma Yanrong Lu Ping Fu Jingping Liu Source Type: research

Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research

Radiosensitizing effects of curcumin alone or combined with GLUT1 siRNA on laryngeal carcinoma cells through AMPK pathway-induced autophagy
In this study, we investigated the ability of curcumin alone or in combination with GLUT1 siRNA to radiosensitize laryngeal carcinoma (LC) through the induction of autophagy. Protein levels in tumour tissues and LC cells were measured by immunohistochemistry and Western blotting. In vitro, cell proliferation, colony formation assays, cell death and autophagy were detected. A nude mouse xenograft model was established through the injection of Tu212 cells. We found that GLUT1 was highly expressed and negatively associated with autophagy-related proteins in LC and that curcumin suppressed radiation-mediated GLUT1 overexpressi...
Source: Molecular Medicine - May 6, 2021 Category: Molecular Biology Authors: Li-Bo Dai Jiang-Tao Zhong Li-Fang Shen Shui-Hong Zhou Zhong-Jie Lu Yang-Yang Bao Jun Fan Source Type: research