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Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPK α1/SIRT1 pathway.
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway. Toxicol Appl Pharmacol. 2017 Dec 15;: Authors: Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J Abstract Carnosic acid (CA), a major bioactive component in rosemary extract, has many biological and pharmaceutical activities. Smad3 acetylation can regulate the transcription of type I α2 collagen (COL1A2), which is the major component of the extracellular matrix (ECM). The aim of the current study was to evaluate whether CA inhibits COL1A2 transcription via the re...
Source: Toxicology and Applied Pharmacology - December 15, 2017 Category: Toxicology Authors: Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J Tags: Toxicol Appl Pharmacol Source Type: research