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Lipoxin A4-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair
The main cause of morbidity and mortality in cystic fibrosis (CF) is progressive lung destruction as a result of persistent bacterial infection and inflammation, coupled with reduced capacity for epithelial repair. Levels of the anti-inflammatory mediator lipoxin A4 (LXA4) have been reported to be reduced in bronchoalveolar lavages of patients with CF. We investigated the ability of LXA4 to trigger epithelial repair through the initiation of proliferation and migration in non-CF (NuLi-1) and CF (CuFi-1) airway epithelia. Spontaneous repair and cell migration were significantly slower in CF epithelial cultures (CuFi-1) comp...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2013 Category: Respiratory Medicine Authors: Buchanan, P. J., McNally, P., Harvey, B. J., Urbach, V. Tags: ARTICLES Source Type: research