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Phosphatase of regenerating liver maintains cellular magnesium homeostasis
Phosphatase of regenerating liver (PRL) is highly expressed in malignant cancers and promotes cancer progression. Recent studies have suggested its functional relationship with Mg2+, but the importance and molecular details of this relationship remain unknown. Here, we report that PRL expression is regulated by Mg2+ and PRL protects cells from apoptosis under Mg2+-depleted conditions. When cultured cells were subjected to Mg2+ depletion, endogenous PRL protein levels increased significantly. siRNA-mediated knockdown of endogenous PRL did not significantly affect cell proliferation under normal culture conditions, but it in...
Source: Biochemical Journal - March 26, 2018 Category: Biochemistry Authors: Yoshida, A., Funato, Y., Miki, H. Tags: Research Articles Source Type: research

Phosphatase of regenerating liver maintains cellular magnesium homeostasis.
Abstract Phosphatase of regenerating liver (PRL) is highly expressed in malignant cancers and promotes cancer progression. Recent studies have suggested its functional relationship with Mg2+, but the importance and molecular details of this relationship remain unknown. Here, we report that PRL expression is regulated by Mg2+ and PRL protects cells from apoptosis under Mg2+-depleted conditions. When cultured cells were subjected to Mg2+ depletion, endogenous PRL protein levels increased significantly. siRNA-mediated knockdown of endogenous PRL did not significantly affect cell proliferation under normal culture con...
Source: The Biochemical Journal - February 27, 2018 Category: Biochemistry Authors: Yoshida A, Funato Y, Miki H Tags: Biochem J Source Type: research