• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Palmitic acid promotes human retinal pigment epithelial cells migration by upregulating miR-222 expression and inhibiting NUMB
This study unravels a novel PA-miR-222-NUMB axis that can be potentially targeted for therapy of high fat acid-related ocular diseases.PMID:37566749 | DOI:10.18632/aging.204647
Source: Aging - August 11, 2023 Category: Biomedical Science Authors: Fengzhi Li Chunling Lei Ke Gong Shuwei Bai Lianyi Sun Source Type: research

Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells
CONCLUSION: These results indicate that inhibition of CDK9 may be a novel therapeutic target for the prevention of atherosclerosis.PMID:34102609 | DOI:10.18632/aging.202998
Source: Aging - June 8, 2021 Category: Biomedical Science Authors: Shushi Huang Wu Luo Gaojun Wu Qirui Shen Zaishou Zhuang Daona Yang Jinfu Qian Xiang Hu Yan Cai Nipon Chattipakorn Weijian Huang Guang Liang Source Type: research

Alisol B 23-acetate activates ABCG5/G8 in the jejunum via the LXR α/ACAT2 pathway to relieve atherosclerosis in ovariectomized ApoE-/- mice.
In conclusion, we confirmed that AB23A can reduce the absorption of dietary lipids in the jejunum by affecting the LXRα-ACAT2-ABCG5/G8 pathway and ultimately exert an anti-atherosclerotic effect. PMID: 33234731 [PubMed - as supplied by publisher]
Source: Aging - November 25, 2020 Category: Biomedical Science Authors: Yu XC, Fu Y, Bi YH, Zhang WW, Li J, Ji T, Chao Y, Meng QH, Chen Q, Ma MH, Zhang YH, Shan J, Bian HM Tags: Aging (Albany NY) Source Type: research

Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy.
In this study, we explored the protective effects and mechanism of AsC on macrophage polarization in atherosclerosis in vivo and in vitro. Using a high-fat diet (HFD)-fed ApoE-/- mouse model and RAW264.7 macrophages exposed to ox-LDL, AsC was evaluated for its effects on polarization and autophagy. AsC significantly reduced the plaque area in atherosclerotic mice and lipid accumulation in ox-LDL-treated macrophages, promoted M2 phenotype macrophage polarization, increased the number of autophagosomes and modulated the expression of autophagy-related proteins. Moreover, the autophagy inhibitor 3-methyladenine and BECN1 siRN...
Source: Aging - January 26, 2020 Category: Biomedical Science Authors: Luo Y, Lu S, Gao Y, Yang K, Wu D, Xu X, Sun G, Sun X Tags: Aging (Albany NY) Source Type: research

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway.
CONCLUSIONS: Resveratrol prevented high-fat diet-induced muscle atrophy in aged rats by reversing mitochondrial dysfunction and oxidative stress, which was partially mediated by the PKA/LKB1/AMPK pathway. These findings indicate that resveratrol might have potential uses for the prevention and treatment of sarcopenic obesity. PMID: 30988232 [PubMed - as supplied by publisher]
Source: Aging - April 14, 2019 Category: Biomedical Science Authors: Huang Y, Zhu X, Chen K, Lang H, Zhang Y, Hou P, Ran L, Zhou M, Zheng J, Yi L, Mi M, Zhang Q Tags: Aging (Albany NY) Source Type: research

Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder.
Abstract Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor that exerts a variety of effects, including anti-inflammatory, immunosuppressive, and anti-tumor effects. The aim of this study was to investigate the effect of rolipram on metabolic disorder and its underlying mechanisms. Metabolic disorder was induced in 8-week-old wild type BABL/c mice by administration of D-galactose for 4 weeks. Simultaneously the mice were administered vehicle or rolipram. Alternatively, beginning at 3 or 21 months, the mice were administered db-cAMP for 3 months, with or without a high-fat-diet (HFD) to induce metabolic d...
Source: Aging - September 18, 2018 Category: Biomedical Science Authors: Wang Z, Liang Y, Zhang L, Zhang N, Liu Q, Wang Z Tags: Aging (Albany NY) Source Type: research