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Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine
Conclusion, high fat and TMA could induce the expression of FMO1 and its metabolite TMAO. When FMO1 is silenced, the effects of high fat and TMA on TMAO are blocked. And the role of TMAO in NAFLD may be through the activation of UPR.PMID:35065293 | DOI:10.1016/j.bbrc.2022.01.060
Source: Biochemical and Biophysical Research communications - January 22, 2022 Category: Biochemistry Authors: Chunxia Shi Maohua Pei Yao Wang Qian Chen Pan Cao Luyi Zhang Jin Guo Wei Deng Luwen Wang Xun Li Zuojiong Gong Source Type: research

Patchouli alcohol improves wound healing in high fat diet-fed mice through AMPK-mediated suppression of inflammation and TGFb1 signaling
Biochem Biophys Res Commun. 2021 May 20;561:136-142. doi: 10.1016/j.bbrc.2021.05.036. Online ahead of print.ABSTRACTObesity impairs wound healing with substantial alterations in skin inflammation. Patchouli alcohol (PA), extracted from patchouli, has been reported to ameliorate inflammation in various cell types. However, the effects of PA on inflammation and wound healing have not been reported to date. In the present study, we examined whether PA affects cutaneous wound healing in high fat diet (HFD)-fed mice and explored PA-mediated molecular mechanisms through in vitro experiments. We found that PA administration accel...
Source: Biochemical and Biophysical Research communications - May 23, 2021 Category: Biochemistry Authors: Tae Jin Kim Do Hyeon Pyun Seung Yeon Park Hyun Jung Lee A M Abd El-Aty Jin-Ho Song Yong Kyoo Shin Ji Hoon Jeong Tae Woo Jung Source Type: research

Liraglutide regulates lipid metabolism via FGF21- LKB1- AMPK- ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice
In conclusion, FGF21 is induced to be expressed in macrophage by LRG, which then activates LKB1-AMPK-ACC1 pathway in an autocrine manner.PMID:33640604 | DOI:10.1016/j.bbrc.2021.02.065
Source: Biochemical and Biophysical Research communications - February 28, 2021 Category: Biochemistry Authors: Nan Zhang Chao Liu Yi Zhang Dongmei Xu Li Gui Yunxia Lu Qiu Zhang Source Type: research

Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions.
CONCLUSIONS: Linagliptin increased M2 macrophage polarization by inhibiting DPP-4 expression and activity. These findings may indicate the beneficial effects of DPP-4 inhibitors on the progression of diabetic macrovascular complications. PMID: 31964532 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - January 17, 2020 Category: Biochemistry Authors: Nishida S, Matsumura T, Senokuchi T, Murakami-Nishida S, Ishii N, Morita Y, Yagi Y, Motoshima H, Kondo T, Araki E Tags: Biochem Biophys Res Commun Source Type: research

PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes.
In this study, we created a high-fat-diet (HFD)-induced obese mouse model and examined the expression of PINK1 and Parkin in adipose tissue using western blot and real-time quantitative PCR. After we confirmed that there is an interesting difference between regular-chow-fed mice and HFD-induced obese mice in the expression of PINK1 and Parkin in vivo, we further tested the expression of PINK1 and Parkin in 3T3-L1 preadipocytes in vitro by treating cells with palmitic acid (PA) to induce metabolic stress. To better understand the role of PINK1 and Parkin in metabolic stress, 3T3-L1 preadipocytes were transfected with small ...
Source: Biochemical and Biophysical Research communications - February 28, 2018 Category: Biochemistry Authors: Cui C, Qiao J, Qing L, Wang L, He T, Wang C, Liu F, Gong L, Chen L, Hou X Tags: Biochem Biophys Res Commun Source Type: research

Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice.
Abstract It has been demonstrated that dietary high fat diet negatively affects the pubertal mammary gland development. The aim of the present study was to investigate the effects of stearic acid (SA), an 18-carbon chain saturated fatty acid, on mammary gland development in pubertal mice and to explore the underlying mechanism. Our results demonstrated that dietary supplementation of 2% SA suppressed mammary duct development, with significant reduction of terminal end bud (TEB) number and ductal branch. In accord, the expression of proliferative marker Cyclin D1 was markedly decreased by dietary SA. Furthermore, d...
Source: Biochemical and Biophysical Research communications - July 13, 2017 Category: Biochemistry Authors: Meng Y, Yuan C, Zhang J, Zhang F, Fu Q, Zhu X, Shu G, Wang L, Gao P, Xi Q, Sun J, Zhang Y, Jiang Q, Wang S Tags: Biochem Biophys Res Commun Source Type: research