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Evaluation of an Integrin α < sub > v < /sub > β < sub > 3 < /sub > Radiotracer, < sup > 18 < /sup > FF-FPP-RGD < sub > 2 < /sub > , for Monitoring Pharmacological Effects of Integrin α < sub > v < /sub > siRNA in the NASH Liver
CONCLUSION: This study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.PMID:37483876 | PMC:PMC10359219 | DOI:10.1007/s13139-023-00791-9
Source: Molecular Medicine - July 24, 2023 Category: Molecular Biology Authors: Shuichi Hiroyama Keiko Matsunaga Miwa Ito Hitoshi Iimori Ippei Morita Jun Nakamura Eku Shimosegawa Kohji Abe Source Type: research

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppar γ-CD36 axis
Exp Mol Med. 2023 Jan 6. doi: 10.1038/s12276-022-00919-5. Online ahead of print.ABSTRACTDynamic alteration of DNA methylation leads to various human diseases, including nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been reported to be associated with NAFLD, its exact underlying mechanism remains unclear. Here, we aimed to elucidate this mechanism in NAFLD in vitro and in vivo. We first identified alterations in the methylation status of the Cmip intron 1 region in mouse liver tissues with high-fat high-sucrose diet-induced NAFLD. Knockdown of DNA methyltransferase (Dnmt) 1 significant...
Source: Molecular Medicine - January 7, 2023 Category: Molecular Biology Authors: Jangho Lee Ji-Hye Song Jae-Ho Park Min-Yu Chung Seung-Hyun Lee Sae-Bom Jeon So Hee Park Jin-Taek Hwang Hyo-Kyoung Choi Source Type: research

miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation
CONCLUSION: Silencing miR-351 upregulates ITGB3 and activates the PIK3R1/Akt pathway, thereby exerting anti-apoptosis and protective effects on endothelial cells.PMID:36180828 | DOI:10.1186/s10020-022-00547-9
Source: Molecular Medicine - September 30, 2022 Category: Molecular Biology Authors: Hong Li Dan Song Qihui Liu Linlin Li Xiaoshi Sun Jiamei Guo Dianlian Li Ping Li Source Type: research

PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
CONCLUSIONS: PACS-2 has a protective role against lipid-related kidney injury in DKD through SOAT1/SREBPs signaling.PMID:36138342 | DOI:10.1186/s10020-022-00545-x
Source: Molecular Medicine - September 22, 2022 Category: Molecular Biology Authors: Chanyue Zhao Li Li Chenrui Li Chengyuan Tang Juan Cai Yu Liu Jinfei Yang Yiyun Xi Ming Yang Na Jiang Yachun Han Yan Liu Shilu Luo Li Xiao Lin Sun Source Type: research

H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes
CONCLUSIONS: Our results suggest a critical role for the lncRNA H19-HDAC6 axis in regulating IRS1 levels in the skeletal muscle during diabetes and therefore restoring normal H19 levels might hold a therapeutic potential for the management of aberrant skeletal muscle physiology during insulin resistance and type 2 diabetes.PMID:35842608 | DOI:10.1186/s10020-022-00507-3
Source: Molecular Medicine - July 16, 2022 Category: Molecular Biology Authors: Amit Kumar Malabika Datta Source Type: research

Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK α/TGF-β/Smad signalling in type 2 diabetic rats
This study aimed to evaluate the effect of SGLT2 inhibitor dapagliflozin (DAPA) on DCM especially for cardiac fibrosis and explore the underlying mechanism. In vivo, the model of type 2 diabetic rats was built with high-fat feeding and streptozotocin injection. Untreated diabetic rats showed cardiac dysfunction, increased myocardial fibrosis and EndMT, which was attenuated after treatment with DAPA and metformin. In vitro, HUVECs and primary cardiac fibroblasts were treated with DAPA and exposed to high glucose (HG). HG-induced EndMT in HUVECs and collagen secretion of fibroblasts were markedly inhibited by DAPA. Up-regula...
Source: Molecular Medicine - June 25, 2021 Category: Molecular Biology Authors: Jingjing Tian Mingjun Zhang Mengying Suo Dian Liu Xuyang Wang Ming Liu Jinyu Pan Tao Jin Fengshuang An Source Type: research