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Proteomic Analysis Reveals PGAM1 Altering cis -9 , trans -11 Conjugated Linoleic Acid Synthesis in Bovine Mammary Gland
In conclusion, our data suggested that PGAM1 may have a negative relationship with SCD1 and seemed to be involved in cis-9, trans-11 CLA synthesis by facilitating the absorption of trans-11 C18:1 in the bovine mammary gland.
Source: Lipids - March 29, 2015 Category: Lipidology Source Type: research

Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3{alpha}/{beta} regulate foam cell formation Research Articles
This study investigated the potential role of glycogen synthase kinase (GSK)-3α/β in proatherogenic ER stress signaling. Thp1-derived macrophages were treated with the ER stress-inducing agents, glucosamine, thapsigargin, or palmitate. Using small-molecule inhibitors of specific unfolded protein response (UPR) signaling pathways, we found that protein kinase R-like ER kinase (PERK), but not inositol requiring enzyme 1 or activating transcription factor 6, is required for the activation of GSK3α/β by ER stress. GSK3α/β inhibition or siRNA-directed knockdown attenuated ER stress-induced expre...
Source: The Journal of Lipid Research - October 29, 2014 Category: Lipidology Authors: McAlpine, C. S., Werstuck, G. H. Tags: Research Articles Source Type: research