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Synthesis and in vitro evaluation of monodisperse amino-functional polyester dendrimers with rapid degradability and antibacterial properties.
Abstract Amine functional polymers, especially cationically charged, are interesting biomacromolecules for several reasons including easy cell membrane entrance, their ability to escape endosomes through the proton sponge effect, spontaneous complexation and delivery of drugs and siRNA and simple functionalization in aqueous solutions. Dendrimers, a subclass of precision polymers, are monodisperse and exhibit a large and exact number of peripheral end groups in relation to their size and have shown promise in drug delivery, biomedical imaging and as anti-viral agents. In this work, hydroxyl functional dendrimers o...
Source: Biomacromolecules - November 13, 2017 Category: Biochemistry Authors: Stenström P, Hjort E, Zhang Y, Andrén OCJ, Guette-Marquet S, Schultzberg M, Malkoch M Tags: Biomacromolecules Source Type: research