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Source: Biochemical Pharmacology
Nutrition: Diets
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Total 20 results found since Jan 2013.
SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3)
CONCLUSIONS: We identified SIRT6 as a new regulator of the activity of NOS3, with functional implications for endothelial-dependent relaxation.PMID:36720357 | DOI:10.1016/j.bcp.2023.115439
Source: Biochemical Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Jiaojiao Wang Zhiping Liu Jing Lu Jiami Zou Weile Ye Hong Li Si Gao Peiqing Liu Source Type: research
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress
Biochem Pharmacol. 2022 Aug 7:115203. doi: 10.1016/j.bcp.2022.115203. Online ahead of print.ABSTRACTResolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. In mouse primary hepatocytes, RD3 ...
Source: Biochemical Pharmacology - August 10, 2022 Category: Drugs & Pharmacology Authors: Heeseung Oh Wonjun Cho A M Abd El-Aty Cemil Bayram Ji Hoon Jeong Tae Woo Jung Source Type: research
HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis
Biochem Pharmacol. 2021 Jul 30:114716. doi: 10.1016/j.bcp.2021.114716. Online ahead of print.ABSTRACTA total number of 18 different isoforms of histone deacetylases (HDACs) which were categorized into 4 classes have been identified in human. HDAC3 is categorized as Class I HDACs and is closely related to the occurrence and development of atherosclerosis. Recent evidence has pointed to endothelial-to-mesenchymal transition (EndMT) as a key process in vascular inflammation in atherosclerosis. However, little is known about the effect of HDAC3 on EndMT in atherosclerosis. Therefore, we aimed to investigate the effect of HDAC3...
Source: Biochemical Pharmacology - August 2, 2021 Category: Drugs & Pharmacology Authors: Lifang Chen Chenxu Shang Bo Wang Guan Wang Zhen Jin Feng Yao Zejun Yue Liang Bai Rong Wang Sihai Zhao Enqi Liu Weirong Wang Source Type: research
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1 α-dependent mitochondrial homeostasis in endothelial cells
Biochem Pharmacol. 2021 Apr 16:114559. doi: 10.1016/j.bcp.2021.114559. Online ahead of print.ABSTRACTRetinoid X receptor beta (RXRβ) has been poorly studied in atherosclerosis. The aim of the present study is to explore the function of RXRβ in oxidized low density lipoprotein (ox-LDL)-induced inflammation in endothelial cells and the underlying mechanism. The protein expression of RXRβ in the aorta of atherosclerotic mice was detected. A lentivirus vector for RXRβ overexpression and RNA interference for RXRβ downregulation were constructed and transfected into human aortic endothelial cells (HAECs). The results showed...
Source: Biochemical Pharmacology - April 19, 2021 Category: Drugs & Pharmacology Authors: Yi Zeng Chun Yan Wang Jin Xu Xiao Le Xu Source Type: research
Resveratrol enhances transintestinal cholesterol excretion through selective activation of intestinal liver X receptor alpha
In conclusion, RSV could decrease circulating cholesterol levels through enhancing TICE and limiting cholesterol absorption via selective activation of intestinal LXRα.PMID:33631191 | DOI:10.1016/j.bcp.2021.114481
Source: Biochemical Pharmacology - February 25, 2021 Category: Drugs & Pharmacology Authors: Juan Pang Huihui Xu Xu Wang Xu Chen Qing Li Qiannan Liu Yiran You Hanyue Zhang Zhongliang Xu Yimin Zhao Yinghui Zhang Yan Yang Wenhua Ling Source Type: research
