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Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo αpyrene.
CONCLUSION: A common UGT1A haplotype, prevalent in 9% (homozygous) of the White population, significantly impairs the expression of UGT1A enzymes in response to the putative tobacco carcinogen BaP and is likely to represent a significant risk factor for reduced detoxification and increased genotoxicity. Coffee was demonstrated to inhibit BaP-induced production of oxidative stress by UGT1A activation, and is therefore an attractive candidate for chemoprotection in risk groups for HCC or other tumors. PMID: 28300668 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 11, 2017 Category: Biology Authors: Kalthoff S, Landerer S, Reich J, Strassburg CP Tags: Free Radic Biol Med Source Type: research