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Abstract B17: Epigenetic regulation of NOTCH oncogenic signaling in breast cancer
Alterations in DNA methylation occur at different stages of cancer, including initiation, and may underlie up-regulation of genes with oncogenic functions. The NOTCH pathway is often overactive in breast cancer and plays roles in cancer development and progression. It is therefore a possible target for anti-cancer strategies. However, the mechanisms of NOTCH regulation in mammary carcinogenesis remain unclear which hinders the development of effective approaches to target this oncogenic pathway. Interestingly, certain dietary compounds such as polyphenols with a stilbenoid structure suppress the NOTCH signals in cancer and...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Lubecka, K., Kurzava, L., Flower, K., Buvala, H., Teegarden, D., Camarillo, I., Flanagan, J. M., Stefanska, B. Tags: Cancer Genomics and Epigenomics Source Type: research