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The focal complex of epithelial cells provides a signalling platform for interleukin‐8 induction in response to bacterial pathogens
We examined the interaction of several bacterial pathogens with host cells, including Campylobacter jejuni, to determine if the FC is required for induction of chemokine signalling in response to bacterial pathogens. Our data indicate that secretion of IL‐8 is triggered by C. jejuni, Helicobacter pylori and Salmonella enterica serovar Typhimurium in response to engagement of β1 integrins. Additionally, we found that the secretion of IL‐8 from C. jejuni infected epithelial cells requires FAK, Src and paxillin, which in turn are necessary for Erk 1/2 recruitment and activation. Targeting the FC component paxillin with s...
Source: Cellular Microbiology - June 2, 2014 Category: Microbiology Authors: Tyson P. Eucker, Derrick R. Samuelson, Mary Hunzicker‐Dunn, Michael E. Konkel Tags: Research Article Source Type: research

The focal complex of epithelial cells provides a signaling platform for interleukin‐8 induction in response to bacterial pathogens
We examined the interaction of several bacterial pathogens with host cells, including Campylobacter jejuni, to determine if the FC is required for induction of chemokine signaling in response to bacterial pathogens. Our data indicate that secretion of IL‐8 is triggered by C. jejuni, Helicobacter pylori, and Salmonella enterica serovar Typhimurium in response to engagement of β1 integrins. Additionally, we found that the secretion of IL‐8 from C. jejuni infected epithelial cells requires FAK, Src, and paxillin, which in turn are necessary for Erk 1/2 recruitment and activation. Targeting the FC component paxillin with ...
Source: Cellular Microbiology - April 29, 2014 Category: Microbiology Authors: Tyson P. Eucker, Derrick R. Samuelson, Mary Hunzicker‐Dunn, Michael E. Konkel Tags: Research Article Source Type: research