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Infectious Disease: Whooping Cough
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cAMP signaling of Bordetella adenylate cyclase toxin through the SHP‐1 phosphatase activates the BimEL‐Bax pro‐apoptotic cascade in phagocytes
Summary
The adenylate cyclase toxin‐hemolysin (CyaA, ACT or AC‐Hly) plays a key role in virulence of Bordetella pertussis. CyaA penetrates myeloid cells expressing the complement receptor 3 (αMβ2 integrin CD11b/CD18) and subverts bactericidal capacities of neutrophils and macrophages by catalyzing unregulated conversion of cytosolic ATP to the key signaling molecule cAMP. We show that the signaling of CyaA‐produced cAMP hijacks, by an as yet unknown mechanism, the activity of the tyrosine phosphatase SHP‐1 and activates the pro‐apoptotic BimEL‐Bax cascade. Mitochondrial hyperpolarization occurred in human THP...
Source: Cellular Microbiology - September 1, 2015 Category: Microbiology Authors: Jawid Nazir Ahmad, Ondrej Cerny, Irena Linhartova, Jiri Masin, Radim Osicka, Peter Sebo Tags: Research article Source Type: research
