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Source: Biochimica et Biophysica Acta (BBA) General Subjects
Infectious Disease: Osteomyelitis

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Total 1 results found since Jan 2013.

Pneumolysin-induced autophagy contributes to inhibition of osteoblast differentiation through downregulation of Sp1 in human osteosarcoma cells
Conclusion: The results suggest that PLY inhibits osteoblast differentiation by downregulation of Sp1 accompanied by induction of autophagy through ROS-mediated regulation of the AMPK/mTOR pathway. General significance: This study proposes a molecular mechanism for inhibition of osteoblast differentiation in response to PLY.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - July 19, 2017 Category: Biochemistry Source Type: research