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Viruses, Vol. 15, Pages 100: RNA Interference Approach Is a Good Strategy against SARS-CoV-2
ng-Huang Shen COVID-19, caused by SARS-CoV-2, created a devastating outbreak worldwide and consequently became a global health concern. However, no verifiable, specifically targeted treatment has been devised for COVID-19. Several emerging vaccines have been used, but protection has not been satisfactory. The complex genetic composition and high mutation frequency of SARS‑CoV‑2 have caused an uncertain vaccine response. Small interfering RNA (siRNA)-based therapy is an efficient strategy to control various infectious diseases employing post-transcriptional gene silencing through the silencin...
Source: Viruses - December 29, 2022 Category: Virology Authors: Ying-Ray Lee Huey-Pin Tsai Chun-Sheng Yeh Chiung-Yao Fang Michael W. Y. Chan Tzu-Yun Wu Cheng-Huang Shen Tags: Article Source Type: research

Viruses, Vol. 13, Pages 2030: Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence
Drosten Jens Kurreck Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected almost 200 million people worldwide and led to approximately 4 million deaths as of August 2021. Despite successful vaccine development, treatment options are limited. A promising strategy to specifically target viral infections is to suppress viral replication through RNA interference (RNAi). Hence, we designed eight small interfering RNAs (siRNAs) targeting the highly conserved 5’-untranslated region (5’-UTR) of SARS-CoV-2. The most promising candidate identified in initial reporter assays, termed siCoV6, targets the ...
Source: Viruses - October 8, 2021 Category: Virology Authors: Beatrice Tolksdorf Chuanxiong Nie Daniela Niemeyer Viola R öhrs Johanna Berg Daniel Lauster Julia M. Adler Rainer Haag Jakob Trimpert Benedikt Kaufer Christian Drosten Jens Kurreck Tags: Article Source Type: research

Viruses, Vol. 13, Pages 1593: Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19
kus Kuhlmann Cleavage of double-stranded RNA is described as an evolutionary conserved host defense mechanism against viral infection. Small RNAs are the product and triggers of post transcriptional gene silencing events. Up until now, the relevance of this mechanism for SARS-CoV-2-directed immune responses remains elusive. Herein, we used high throughput sequencing to profile the plasma of active and convalescent COVID-19 patients for the presence of small circulating RNAs. The existence of SARS-CoV-2 derived small RNAs in plasma samples of mild and severe COVID-19 cases is described. Clusters of high siRNA abundance ...
Source: Viruses - August 11, 2021 Category: Virology Authors: Claudius Grehl Christoph Schulthei ß Katrin Hoffmann Mascha Binder Thomas Altmann Ivo Grosse Markus Kuhlmann Tags: Brief Report Source Type: research

Viruses, Vol. 13, Pages 270: Synthetic Messenger RNA-Based Vaccines: from Scorn to Hype
o In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are based on attenuated mRNA viruses, such as Mumps, Measles, and Rubella, immunize by delivering their mRNAs into the cells of the vaccinated individual, who produces the viral proteins that then prime the immune response. Synthetic mRNA in liposomes can be seen as a modern, more refined, and thereby a safer version of those live attenuated RNA viruses. The anti-COVID-...
Source: Viruses - February 9, 2021 Category: Virology Authors: Steve Pascolo Tags: Review Source Type: research