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Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:36730646 | DOI:10.1165/rcmb.2022-0331OC
Source: Mol Biol Cell - February 2, 2023 Category: Molecular Biology Authors: Joseph S Bednash Finny Johns Daniela Farkas Ajit Elhance Jessica Adair Kirstin Cress Jacob S Yount Adam D Kenney James D Londino Rama K Mallampalli Source Type: research

High D-glucose levels induce ACE2 expression via GLUT1 in human airway epithelial cell line Calu-3
CONCLUSIONS: This is the first report indicating that high D-glucose levels induced ACE2 expression via GLUT1 in bronchial submucosal cells in vitro. As hyperglycemia can be treated appropriately, these findings could help reduce the risk of worsening of coronavirus disease 2019.PMID:35836103 | DOI:10.1186/s12860-022-00427-4
Source: Mol Biol Cell - July 14, 2022 Category: Molecular Biology Authors: Yoshitaka Wakabayashi Shin Nakayama Ai Yamamoto Takatoshi Kitazawa Source Type: research

Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets
Mol Syst Biol. 2021 Nov;17(11):e10260. doi: 10.15252/msb.202110260.ABSTRACTTremendous progress has been made to control the COVID-19 pandemic caused by the SARS-CoV-2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this urgent unmet medical need. Viruses, including coronaviruses, are known to hijack host metabolism to facilitate viral proliferation, making targeting host metabolism a promising antiviral approach. Here, we describe an integrated analysis of 12 published in vitro and human patient gene expression datasets on SARS-CoV-2 i...
Source: Mol Biol Cell - October 28, 2021 Category: Molecular Biology Authors: Kuoyuan Cheng Laura Martin-Sancho Lipika R Pal Yuan Pu Laura Riva Xin Yin Sanju Sinha Nishanth Ulhas Nair Sumit K Chanda Eytan Ruppin Source Type: research