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Targeted inhibition of Hantavirus replication and intracranial pathogenesis by a chimeric protein-delivered siRNA
Publication date: Available online 7 October 2017 Source:Antiviral Research Author(s): Jie Yang, Ji-Feng Sun, Ting-Ting Wang, Xiao-Hong Guo, Jun-Xia Wei, Lin-Tao Jia, An-Gang Yang Hantavirus (HV) infection, which underlies hantavirus hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, remains to be a severe clinical challenge. Here, we synthesized small interfering RNAs (siRNAs) that target the encoding sequences of HV strain 76-118, and validated their inhibitory role in virus replication in HV-infected monkey kidney Vero E6 cells. A chimeric protein, 3G1-Cκ-tP, consisting of a single-chain antibody...
Source: Antiviral Therapy - October 8, 2017 Category: Virology Source Type: research