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Targeted inhibition of Hantavirus replication and intracranial pathogenesis by a chimeric protein-delivered siRNA.
Abstract Hantavirus (HV) infection, which underlies hantavirus hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, remains to be a severe clinical challenge. Here, we synthesized small interfering RNAs (siRNAs) that target the encoding sequences of HV strain 76-118, and validated their inhibitory role in virus replication in HV-infected monkey kidney Vero E6 cells. A chimeric protein, 3G1-Cκ-tP, consisting of a single-chain antibody fragment (3G1) against the HV surface envelop glycoprotein, the constant region of human immunoglobulin κ chain (Cκ), and truncated protamine (amino acids 8-29,...
Source: Antiviral Research - October 7, 2017 Category: Virology Authors: Yang J, Sun JF, Wang TT, Guo XH, Wei JX, Jia LT, Yang AG Tags: Antiviral Res Source Type: research