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Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus ‐Infected Liver Cells by Up‐Regulating USP18
ConclusionsWe conclude that Ach disrupts IFNα‐induced STAT1 phosphorylation by the up‐regulation of USP18 to block the innate immunity protection in HCV‐infected liver cells, thereby contributing to HCV‐alcohol pathogenesis. This, in part, may explain the mechanism of HCV‐infection exacerbation/progression in alcohol‐abusing patients. IFNα is an important innate immunity factor, which controls HCV replication and spread via the JAK‐STAT1 pathway activation. Here, we investigated the mechanisms which major ethanol metabolite, acetaldehyde, uses to enhance HCV RNA by decreasing IFNα‐induced STAT1 phosphor...
Source: Alcoholism: Clinical and Experimental Research - September 25, 2016 Category: Addiction Authors: Murali Ganesan, Larisa Y. Poluektova, Dean J. Tuma, Kusum K. Kharbanda, Natalia A. Osna Tags: Original Article Source Type: research