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Source: Frontiers in cellular and infection microbiology
Infectious Disease: Arenaviruses
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Junin Virus Activates p38 MAPK and HSP27 Upon Entry
JunÃn virus (JUNV), a New World arenavirus, is a rodent-borne virus and the causative agent of Argentine hemorrhagic fever. Humans become infected through exposure to rodent host secreta and excreta and the resulting infection can lead to an acute inflammatory disease with significant morbidity and mortality. Little is understood about the molecular pathogenesis of arenavirus hemorrhagic fever infections. We utilized Reverse Phase Protein Microarrays (RPPA) to compare global alterations in the host proteome following infection with an attenuated vaccine strain, Candid#1 (CD1), and the most parental virulent strain, XJ13, ...
Source: Frontiers in cellular and infection microbiology - April 7, 2022 Category: Microbiology Source Type: research
