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Infectious Disease: Arenaviruses
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Viruses, Vol. 15, Pages 105: Topoisomerase II as a Novel Antiviral Target against Panarenaviral Diseases
ro Yasuda
Although many arenaviruses cause severe diseases with high fatality rates each year, treatment options are limited to off-label use of ribavirin, and a Food and Drug Administration (FDA)-approved vaccine is not available. To identify novel therapeutic candidates against arenaviral diseases, an RNA polymerase I-driven minigenome (MG) expression system for Lassa virus (LASV) was developed and optimized for high-throughput screening (HTS). Using this system, we screened 2595 FDA-approved compounds for inhibitors of LASV genome replication and identified multiple compounds including pixantrone maleate, a topoisom...
Source: Viruses - December 30, 2022 Category: Virology Authors: Tosin Oladipo Afowowe Yasuteru Sakurai Shuzo Urata Vahid Rajabali Zadeh Jiro Yasuda Tags: Article Source Type: research
