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Source: Antiviral Therapy
Infectious Disease: Arenaviruses
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Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses
Publication date: Available online 19 July 2018Source: Antiviral ResearchAuthor(s): Eric C. Dunham, Anne Leske, Kyle Shifflett, Ari Watt, Heinz Feldmann, Thomas Hoenen, Allison GrosethAbstractInfection with JunÃn virus (JUNV) is currently being effectively managed in the endemic region using a combination of targeted vaccination and plasma therapy. However, the long-term sustainability of plasma therapy is unclear and similar resources are not available for other New World arenaviruses. As a result, there has been renewed interest regarding the potential of drug-based therapies. To facilitate work on this issue, we presen...
Source: Antiviral Therapy - July 20, 2018 Category: Virology Source Type: research