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ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress
Ebola (EBOV) is an enveloped, negative-sense RNA virus belonging to the family Filoviridae that causes hemorrhagic fever syndromes with high-mortality rates. To date, there are no licensed vaccines or therapeutics to control EBOV infection and prevent transmission. Consequently, the need to better understand the mechanisms that regulate virus transmission is critical to developing countermeasures. The EBOV VP40 matrix protein plays a central role in late stages of virion assembly and egress, and independent expression of VP40 leads to the production of virus-like particles (VLPs) by a mechanism that accurately mimics buddi...
Source: The Journal of Infectious Diseases - September 9, 2015 Category: Infectious Diseases Authors: Han, Z., Madara, J. J., Liu, Y., Liu, W., Ruthel, G., Freedman, B. D., Harty, R. N. Tags: MOLECULAR BIOLOGY Source Type: research