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UHRF1 silences gelsolin to inhibit cell death in early stage cervical cancer.
Abstract Persistent infection with high-risk strains of human papillomavirus (HPV) is the primary cause of cervical cancer, the fourth most common cancer among women worldwide. Two oncoproteins encoded by the HPV genome, E6 and E7, are required for epigenetic modifications that promote cervical cancer development. We found that knockdown of HPV E6/E7 by siRNA reduced the levels of ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) but increased the levels of gelsolin (GSN) in early stage cervical cancer cells. In addition, we found that UHRF1 levels were increased and GSN levels were decreased in early...
Source: Biochemical and Biophysical Research communications - April 16, 2020 Category: Biochemistry Authors: Lee HJ, Kim MJ, Kim YS, Choi MY, Cho GJ, Choi WS Tags: Biochem Biophys Res Commun Source Type: research